✦ LIBER ✦

Grb2 SH2 domain-binding peptide analogs as potential anticancer agents

✍ Scribed by Feng-Di T. Lung; Jya-Yin Tsai

Publisher: Wiley (John Wiley & Sons)
Year: 2003
Tongue: English
Weight: 111 KB
Volume: 71
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.10396

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Development of non-phosphorylated cyclic

Development of non-phosphorylated cyclic thioether peptide binding to the Grb2-SH2 domain

✍ Feng-Di T. Lung; C. Richter King; Peter P. Roller 📂 Article 📅 1999 🏛 Springer Netherlands 🌐 English ⚖ 400 KB

Development of Grb2 SH2 Domain Signaling

Development of Grb2 SH2 Domain Signaling Antagonists: A Potential New Class of Antiproliferative Agents

✍ Terrence R. Burke 📂 Article 📅 2006 🏛 Springer Netherlands 🌐 English ⚖ 424 KB

Calorimetric investigation of phosphoryl

Calorimetric investigation of phosphorylated and non-phosphorylated peptide ligand binding to the human Grb7-SH2 domain

✍ A. M. Spuches; H. J. Argiros; K. H. Lee; L. Lowell Haas; S. C. Pero; D. N. Krag; 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB

## Abstract Grb7 is a member of the Grb7 family of proteins, which also includes Grb10 and Grb14. All three proteins have been found to be overexpressed in certain cancers and cancer cell lines. In particular, Grb7 (along with the receptor tyrosine kinase erbB2) is overexpressed in 20–30% of breast

Utilization of a Common Pathway for the

Utilization of a Common Pathway for the Synthesis of High Affinity Macrocyclic Grb2 SH2 Domain-Binding Peptide Mimetics That Differ in the Configuration at One Ring Junction

✍ Zhen-Dan Shi; Rajeshri G. Karki; Karen M. Worthy; Lakshman K. Bindu; Marc C. Nic 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 206 KB

Ring-Closing Metathesis of C-Terminal Al

Ring-Closing Metathesis of C-Terminal Allylglycine Residues with an N-Terminal β-Vinyl-Substituted Phosphotyrosyl Mimetic as an Approach to Novel Grb2 SH2 Domain-Binding Macrocycles

✍ Shinya Oishi; Zhen-Dan Shi; Karen M. Worthy; Lakshman K. Bindu; Robert J. Fisher 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 182 KB

Synthesis and in vitro evaluation of N-a

Synthesis and in vitro evaluation of N-alkyl-3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs as potential anticancer agents

✍ Narsimha Reddy Penthala; Thirupathi Reddy Yerramreddy; Nikhil Reddy Madadi; Pete 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 230 KB

A series of novel 3-hydroxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)indolin-2-one analogs (3) have been synthesized under microwave irradiation and conventional heating methods. These analogs were evaluated for in vitro cytotoxicity against a panel of 57 human tumor cell lines. Compound 3o had GI