𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Grb10 adapter protein as regulator of insulin-like growth factor receptor signaling

✍ Scribed by Andrea Morrione

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
172 KB
Volume
197
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Grb10 is a member of a superfamily of adapter proteins that includes Grb10, 7, 14, and a protein of Caenorhabditis elegans called Mig10. Grb10 proteins are binding partners for several trans‐membrane tyrosine‐kinase receptors, including the insulin‐like growth factor receptor (IGF‐IR) and the insulin receptor (IR). Many recent reports have suggested a very important role of Grb10 in regulating IGF‐IR signaling. In this review, we will focus on the role of Grb10 in IGF‐I‐induced mitogenesis and we will discuss the recent findings that show the involvement of Grb10 in the regulation of ligand‐induced ubiquitination, internalization, and stability of the IGF‐IR. J. Cell. Physiol. 197: 307–311, 2003© 2003 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Grb10/Nedd4-mediated multiubiquitination
Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization
✍ Giada Monami; Velia Emiliozzi; Andrea Morrione 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 622 KB

## Abstract The adaptor protein Grb10 is an interacting partner of the IGF‐I receptor (IGF‐IR) and the insulin receptor (IR). Previous work from our laboratory has established the role of Grb10 as a negative regulator of IGF‐IR‐dependent cell proliferation. We have shown that Grb10 binds the E3 ubi

Growth factor regulation of insulin-like
Growth factor regulation of insulin-like growth factor binding protein-6 expression in osteoblasts
✍ Bari Gabbitas; Ernesto Canalis 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 238 KB 👁 2 views

Previously we have shown that transforming growth factor b (TGF b) 1, basic fibroblast growth factor (FGF), and platelet-derived growth factor (PDGF) BB inhibit the synthesis of insulin-like growth factor (IGF) II, but their effects on IGF binding protein (IGFBP)-6 in osteoblast cultures are not kno

Estradiol and progesterone regulate the
Estradiol and progesterone regulate the expression of insulin-like growth factor-I receptor and insulin-like growth factor binding protein-2 in the hypothalamus of adult female rats
✍ Cardona-G�mez, G. P. ;Chowen, J. A. ;Garcia-Segura, L. M. 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 676 KB

## Gonadal hormones interact with in- sulin-like growth factor-I (IGF-I) to regulate synaptic plasticity during the estrous cycle in the rat mediobasal hypothalamus. It has been proposed that tanycytes, specialized glial cells lining the ventral region of the third ventricle, may regulate the avail

Role of insulin-like growth factor-I in
Role of insulin-like growth factor-I in regulating estrogen receptor-α gene expression
✍ Adriana Stoica; Miguel Saceda; Amina Fakhro; Michael Joyner; Mary Beth Martin 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB 👁 1 views

The role of insulin-like growth factor-I (IGF-I) in regulating estrogen receptor-␣ (ER-␣) gene expression and activity was investigated in the human breast cancer cell line MCF-7. Treatment of cells with 40 ng/ml IGF-I resulted in a 60% decrease in ER-␣ protein concentration by 3 h, and the amount o