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Gray matter pathology and multiple sclerosis

✍ Scribed by Christiane Wegner; Christine Stadelmann


Publisher
Springer
Year
2009
Tongue
English
Weight
226 KB
Volume
9
Category
Article
ISSN
1528-4042

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## Abstract Oxidative stress has been implicated in the pathophysiology of multiple sclerosis (MS). Increased levels of reactive oxygen species (ROS) derived from infiltrating macrophages and microglial cells have been shown to reduce the levels of endogenous antioxidants and to cause the oxidation

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## Abstract ## Objective To determine the relation of gray matter (GM) and white matter (WM) brain volumes, and WM lesion load, with clinical outcomes 20 years after first presentation with clinically isolated syndrome suggestive of multiple sclerosis (MS). ## Methods Seventy‐three patients were