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Gravimetric measurement of momentary drying rate of spray freeze-dried powders in vials

โœ Scribed by Gieseler, Henning (author);Lee, Geoffrey (author)

Publisher
John Wiley and Sons Inc.
Year
2009
Tongue
English
Weight
413 KB
Volume
98
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

The profile of drying rate versus primary drying time for a spray freezedried trehalose aqueous solution is much different from that determined for regular freeze-drying. Drying rate declines very rapidly, attributed to rate-limiting heat transfer through the packed bed of frozen microparticles contained in a vial. The inter-particulate spaces appear to be the cause of this rate limitation. Use of either liquid nitrogen or liquid propane as a cryogenic produced strong differences in both SFD particle morphology and drying rate using trehalose, sucrose, or mannitol. The lack of any evident correlation supports the argument that the inter-particulate voids determine drying behavior.

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โœ Claudia Roth; Gerhard Winter; Geoffrey Lee ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 351 KB

The use of a novel microbalance (Christ) technique to monitor continuously the weight loss of a vial standing on a shelf of a freeze-dryer has been investigated. The drying rates of the following aqueous solutions were measured during the primary drying phase of a complete freeze-drying cycle: sucro