Graphite Micropowder Modified with 4-Amino-2,6-diphenylphenol Supported on Basal Plane Pyrolytic Graphite Electrodes: Micro Sensing Platforms for the Indirect Electrochemical Detection of Δ9-Tetrahydrocannabinol in Saliva
✍ Scribed by Alexander Goodwin; Craig E. Banks; Richard G. Compton
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 512 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1040-0397
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✦ Synopsis
Abstract
Graphite micropowder has been modified with 4‐amino‐2,6‐diphenylphenol immobilized onto a basal plane pyrolytic graphite electrode and explored for the indirect electrochemical sensing of Δ^9^‐tetrahydrocannabinol in artificial saliva. The protocol is based on the electrochemical formation of quinoneimine which specifically reacts with Δ^9^‐tetrahydrocannabinol resulting in the loss of the quinoneimine which can be monitored via voltammetry. It is demonstrated that Δ^9^‐tetrahydrocannabinol can be detected in artificial saliva over the micromolar range. Such a protocol may find application in screening for drug abuse.