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The cover picture shows a branched poly(proline) peptide whose synthesis has successfully been achieved using a combination of step-wise and convergent solid-phase peptide methodology. Aminoproline was used as a branching unit in order to maintain structural coherence with the rest of the sequence, although other trifunctional amino acids were also tested. Assembly of different units of this peptide could lead to poly(proline) dendrimers. These new biocompatible architectures may have interesting applications in drug-delivery. Details are discussed in the article by F. Albericio et al. on p. 1756 ff.
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The cover picture shows a space-filling representation of an intrinsically unsymmetrical porphyrazine containing a transition metal ion within its central cavity (C atoms in green, N atoms in red, metal atom in yellow and H atoms in white). The formal substitution of a pyrrole ring in a metalloporph