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The cover picture shows a schematic representation of how collagen-induced arthritis, a model for rheumatoid arthritis, is induced in mice by immunization with type II collagen. Immunization leads to presentation of glycopeptide antigens by major histocompatibility complex (MHC) molecules to T cells. By using a panel of synthetic glycopeptides, the T cells were found to recognize the galactose moiety attached to hydroxylysine 264 in the type II collagen fragment CII256-270. These results, and knowledge of which amino acids anchor CII256-270 in the cleft of the class II MHC molecule, were used to generate the structural model of the glycopeptideΒ±MHC complex also shown in the cover picture. Further details can be found in the article by Kihlberg and co-workers on p. 1209 ff. (We thank BjΛrn Holm and Andreas Larsson for assistance in the preparation of the cover picture.)
π SIMILAR VOLUMES
## 683 COVER PICTURE The cover picture shows a view of the hammerhead ribozyme from the major groove side of the junction. In this view, the catalytic domain 1 is on the left side, with the scissile phosphodiester bond arrowed. Domain 2, which mediates the interaction between the coaxially stacked