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Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans

✍ Scribed by Soons, Paul A; Vogels, Birgit A P M; Roosemalen, Margret C M; Schoemaker, Hendrik C; Uchida, Eiji; Edgar, Boo; Lundahl, Jonas; Cohen, Adam F; Breimer, Douwe D


Book ID
109844948
Publisher
Nature Publishing Group
Year
1991
Tongue
English
Weight
560 KB
Volume
50
Category
Article
ISSN
0009-9236

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To investigate the potential interaction between selected ingredients of grapefruit juice and, the transport of talinolol, a P-gp substrate, across Caco-2 cells monolayers was determined in the absence and presence of distinct concentrations of grapefruit juice, bergamottin, 6 0 ,7 0 -dihydroxyberga