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Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

✍ Scribed by Toyonori Kato; Hitoshi Shimano; Takashi Yamamoto; Tomotaka Yokoo; Yuko Endo; Mayumi Ishikawa; Takashi Matsuzaka; Yoshimi Nakagawa; Shin Kumadaki; Naoya Yahagi; Akimitsu Takahashi; Hirohito Sone; Hiroaki Suzuki; Hideo Toyoshima; Alyssa H. Hasty; Satoru Takahashi; Hiroshi Gomi; Tetsuro Izumi; Nobuhiro Yamada


Book ID
116372481
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
935 KB
Volume
4
Category
Article
ISSN
1550-4131

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## Abstract Impairment of glucose‐stimulated insulin secretion (GSIS) caused by glucolipotoxicity is an essential feature in type 2 diabetes mellitus (T2DM). Palmitate and eicosapentaenoate (EPA), because of their lipotoxicity and protection effect, were found to impair or restore the GSIS in beta