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Granulocyte—macrophage colony-stimulating factor inhibits tumour growth

✍ Scribed by A. D. K. Hill; Professor H. P. Redmond; O. M. Austin; P. A. Grace; D. Bouchier-Hayes

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
421 KB
Volume
80
Category
Article
ISSN
0007-1323

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✦ Synopsis

G ranu locyte-macro phage colony-stimulating factor in hi bits tumour growth

The efSect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on murine antitumour responses was examined. Sixty mice received Lewis lung carcinoma implants and were then randomized to receive GM-CSF 1 pglday, GM-CSF0.5 pglday or saline for I0 days and studied with regard to tumour volume, carcass weight and food intake. Macrophage antitumour mechanisms including oxygen free radical production and nitric oxide release were studied in peritoneal macrophages after co-culture with GM-CSF in vitro and in vivo. GM-CSF 1 pglday decreased tumour growth after 5 days (mean(s.e.m.) 0.62(0.14) versus 1.24(0.19) ern3, P = 0.01 7). GM-CSF upregulated macrophage antitumour mechanisms by enhancing the in vivo production of superoxide radicals (mean( s.e.m. ) 0-69( 0.06) versus 0*45(0.10) nmol, P < 0.05) andnitric oxide (mean(s.e.m.) 48(3) versus 24(4) pmol, P < 0.01). GM-CSF functions through the enhancement of macrophage tumoricidal activity, suggesting a therapeutic potential for this cytokine in the tumour-bearing host.

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