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Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cells

โœ Scribed by Toshiki Tomita; Masato Fujii; Yutaka Tokumaru; Yorihisa Imanishi; Minoru Kanke; Taku Yamashita; Ryuichiro Ishiguro; Jin Kanzaki; Kaori Kameyama; Yoshihide Otani


Book ID
117466548
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
267 KB
Volume
156
Category
Article
ISSN
0304-3835

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Vascular endothelial growth factor (VEGF) is the major endothelial mitogen in central nervous system neoplasms and it is expressed in 64-95% of glioblastomas (GBMs). Tumour cells are the main source of VEGF in GBMs whereas VEGF receptors (VEGFR-1, its soluble form sVEGFR-1, VEGFR-2 and neuropilin-1)