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Granulocyte-macrophage colony-stimulating factor (GM-CSF) primes the respiratory burst and stimulates protein biosynthesis in human neutrophils

✍ Scribed by Steven W. Edwards; Charlotte S. Holden; John M. Humphreys; C.Anthony Hart


Book ID
115922771
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
540 KB
Volume
256
Category
Article
ISSN
0014-5793

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) (250 microg/m2) was administered subcutaneously to 7 normal volunteers for up to 14 days to study its effects on neutrophil kinetics and function. With treatment, blood neutrophil counts rose gradually to peak at 3 1/2 times baseline by day 1