Granulocyte-macrophage colony-stimulating factor given as an adjuvant to persons not responding to hepatitis B vaccine

Effects of granulocyte-macrophage colony

Effects of granulocyte-macrophage colony-stimulating factor and foreign helper protein as immunologic adjuvants on the T-cell response to vaccination with tyrosinase peptides

✍ Carmen Scheibenbogen; Dirk Schadendorf; Nikolaos E. Bechrakis; Dirk Nagorsen; Ud 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 316 KB

## Abstract Immunologic adjuvants are used to augment the immunogenicity of MHC class I–restricted peptide vaccines, but this effect has rarely been systematically evaluated in a clinical trial. We have investigated, in a phase I study, whether addition of the 2 adjuvants GM‐CSF and KLH can enhance