Granulocyte colony-stimulating factor (G-CSF) induces synthesis of alkaline phosphatase in neutrophilic granulocytes of chronic myelogenous leukemia patients
✍ Scribed by G. Chikkappa; G.J. Wang; D. Santella; D. Pasquale
- Book ID
- 113239030
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 761 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0145-2126
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## Abstract ## BACKGROUND Imatinib mesylate administration has become standard treatment for patients with chronic myelogenous leukemia (CML). Although the safety profile of imatinib is favorable, Grade ≥ 3 neutropenia (according to the National Cancer Institute Common Toxicity Criteria) occurs in
I 1 3 (F.T.), lapan We have previously shown that a factor termed neutrophil alkaline phosphataseinducing factor (NAP-IF) has the capacity to induce neutrophil alkaline phosphatase (NAP) in postmitotic granulocytes (PMGs). This factor has characteristics similar to those of granulocyte colony-stimu