Granulocyte Colony-Stimulating Factor Enhances Interleukin 3-Dependent Proliferation of Multipotential Hemopoietic Progenitors
✍ Scribed by Kenji Ikebuchi, Steven C. Clark, James N. Ihle, Lawrence M. Souza and Makio Ogawa
- Book ID
- 123635551
- Publisher
- National Academy of Sciences
- Year
- 1988
- Tongue
- English
- Weight
- 838 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/31679
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Combinations of low dosages of purified recombinant human (rh) macrophagecolony stimulating factor (M-CSF; also termed CSF-1) and rh granulocyte-colony stimulating factor (G-CSF) were compared alone and in combination for their influence on the cycling rates and numbers of bone marrow and splenic gr
## Abstract We studied the effects of interleukin‐3 (IL‐3) on colony formation by hemopoietic progenitors in methylcellulose cultures of spleen cells from 5‐fluorouracil (FU)‐treated mice. Purified IL‐3 supported the growth of various types of multilineage colonies including blast cell colonies. Th