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Granulocyte colony-stimulating factor and neutrophils—forgotten mediators of inflammatory disease

✍ Scribed by Eyles, Jo L; Roberts, Andrew W; Metcalf, Donald; Wicks, Ian P

Book ID
126607672
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
399 KB
Volume
2
Category
Article
ISSN
1745-8382

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) is produced in large quantities by synoviocytes in the inflamed arthritic joint and is known to be a neutrophil activator. Neutrophils predominate during acute flares of arthritis and are important mediators of cartilage destruction. In this