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Granule strength as a formulation factor I: Instrumentation

✍ Scribed by Gerald Gold; Ronald N. Duvall; Blaze T. Palermo; Richard L. Hurtle

Publisher
John Wiley and Sons
Year
1971
Tongue
English
Weight
403 KB
Volume
60
Category
Article
ISSN
0022-3549

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✦ Synopsis

Although it is recognized that granule strength is an important property of powders influencing pharmaceutical processes, little information has been published on the subject. This lack of information is due mainly to difficulty in obtaining quantitative n,easurement of granule strength and, therefore, in obtaining meaningful data. To meet this need, instrumentation was constructed. It consists of a mechanical linkage to apply a compressive load at a uniform rate and a strain-gauge instrumented cantilever beam to convert the load to a proportional millivolt response which is measured on a recorder. A granule is placed on the platform of the cantilever beam, and an overhead cam depresses a plunger which compresses the granule. The reaction of the granule is obtained on a recorder tracing from which the stress pattern is analyzed and the crushing strength calculated.

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