Granule cell hyperexcitability in the early post-traumatic rat dentate gyrus: the ‘irritable mossy cell’ hypothesis
✍ Scribed by Vijayalakshmi Santhakumar; Roland Bender; Michael Frotscher; Stephen T. Ross; Greg S. Hollrigel; Zsolt Toth; Ivan Soltesz
- Book ID
- 111119017
- Publisher
- Cambridge University Press
- Year
- 2000
- Tongue
- English
- Weight
- 940 KB
- Volume
- 524
- Category
- Article
- ISSN
- 0022-3751
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Mossy cells give rise to the commissural and associational pathway of the dentate gyrus, and receive their major excitatory inputs from the mossy fibers of granule cells. Through these feed-back excitatory connections, mossy cells have been suggested to play important roles in both normal signal pro
Synaptic contacts on the granule cell somata as well as on their axon initial segments in the dentate gyrus of one juvenile 5-week-old rat and one adult 12-week-old rat were analyzed in an electron microscopic serial-sectioning study. In the dentate gyrus of the juvenile rat, somata of 17 granule ce