Granule cell dispersion develops without neurogenesis and does not fully depend on astroglial cell generation in a mouse model of temporal lobe epilepsy

Impaired reelin processing and secretion

Impaired reelin processing and secretion by Cajal–Retzius cells contributes to granule cell dispersion in a mouse model of temporal lobe epilepsy

✍ Venceslas Duveau; Amrita Madhusudan; Matteo Caleo; Irene Knuesel; Jean-Marc Frit 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 694 KB

## Abstract Cajal–Retzius cells play a crucial role during ontogeny in regulating cortical lamination via release of reelin. In adult brain, they comprise small calretinin‐positive interneurons located in the marginal zone of the cerebral cortex and in the hippocampal fissure. Alterations of reelin