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Granisetron as antiemetic therapy in children with cancer

✍ Scribed by Craft, A. W. ;Price, L. ;Eden, O. B. ;Shaw, P. ;Campbell, R. ;Pierce, D. M. ;Murdoch, R. ;Upward, J.

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 377 KB
Volume: 25
Category: Article
ISSN: 0098-1532
DOI: 10.1002/mpo.2950250107

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✦ Synopsis

Abstract

The safety and efficacy of the new 5HT‐3 antagonist granisetron as an antiemetic in children with cancer was evaluated in 40 children at a single dose of 40 μg/kg. No adverse affects attributable to the granisetron were noted. The overall major and complete response rate was 82.5% and this was highest in the younger children. Only 2 patients showed no response. Pharmacokinetic studies showed associations between some pharmacokinetic parameters and age which were no longer apparent after normalisation for body weight.

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