Grafting of silica with sulfobetaine polymers via aqueous reversible addition fragmentation chain transfer polymerization and its use as a stationary phase in HILIC

✍ Scribed by Erika Wikberg; Jeroen J. Verhage; Camilla Viklund; Knut Irgum

• Book ID: 102924742
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 503 KB
• Volume: 32
• Category: Article
• ISSN: 1615-9306
• DOI: 10.1002/jssc.200800554

✦ Synopsis

Abstract

Porous silica particles of 3 μm diameter and 100 Å nominal pore size were first activated for vinylic polymerization by functionalization with 3‐methacryloyloxypropyl trimethoxysilane (MAPTMS) and thereafter dressed with zwitterionic grafts of the sulfoalkylbetaine type in the “grafting through” fashion by polymerizing 3‐(2‐(N‐methacryloyloxyethyl)‐N,N‐dimethylammonio)propane sulfonate (SPE), using either free radical polymerization or controlled reversible addition fragmentation chain transfer polymerization (RAFT). Particles polymerized using RAFT had a lower overall coating which seemed to be more evenly distributed in the pore volume. Both approaches resulted in columns with similar separation properties in HILIC mode.