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Grafting of poly(vinyl pyrrolidone) onto gelatin and its application as synthetic plasma expander

✍ Scribed by K. Raghunath; K. Panduranga Rao; B. Nagarajan; K. Thomas Joseph

Book ID: 103071451
Publisher: Elsevier Science
Year: 1985
Tongue: English
Weight: 419 KB
Volume: 21
Category: Article
ISSN: 0014-3057
DOI: 10.1016/0014-3057(85)90053-9

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✦ Synopsis

Grafting of N-vinyl pyrrolidone onto gelatin is reported using ~,2'-azobisisobutyronitrile as initiator. The effects of various variables like initiator concentration, monomer concentration, time and temperature are reported. These variables appreciably affect the percentage grafting, grafting efficiency and molecular weight of the grafted chain. The graft copolymers were characterized by i.r. spectroscopy and ninhydrin tests. Sulphathiazole was coupled to these graft copolymers using a diazotization technique. Blood compatibility of these graft copolymers of different side chain molecular weight was found to be satisfactory.

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