Grafting of PEO to glass, nitinol, and pyrolytic carbon surfaces by ? irradiation

✍ Scribed by McPherson, Timothy B. ;Shim, Hong S. ;Park, Kinam

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 542 KB
• Volume: 38
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/(sici)1097-4636(199724)38:4<289::aid-jbm1>3.0.co;2-k

✦ Synopsis

Glass, nitinol, and pyrolytic carbon surfaces were grafted with poly (ethylene oxide) (PEO) and PEO-containing Pluronic surfactants by gamma irradiation. These substrates were coated with a primer layer of trichlorovinylsilane (TCVS), which allows grafting of organic polymers. The TCVS-coated substrates were adsorbed with PEO or Pluronics and exposed to 0.3 Mrad of gamma radiation to graft the polymer to the surface. PEO-grafted substrates were characterized by contact angle measurement, X-ray photoelectron spectroscopy, fibrinogen adsorption, and platelet adhesion and activation. Surface modification with PEO reduced fibrinogen adsorption by as much as 99%. Platelet adhesion was significnatly reduced or prevented on the modified surfaces. Protein- and platelet-resistance effects were independent of hydrophilicity of the PEO-grafted surfaces. Polymer grafting by gamma radiation to TCVS-coated substrates provides a facile process to improve thromboresistance of inorganic biomaterials.