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Grafted gelatin microspheres as potential pH-responsive devices

✍ Scribed by U. G. Spizzirri; F. Iemma; I. Altimari; M. Curcio; F. Puoci; N. Picci

Book ID
106397216
Publisher
Springer
Year
2012
Tongue
English
Weight
496 KB
Volume
47
Category
Article
ISSN
0022-2461

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Gelatin-methotrexate microspheres for intra-tumor administration have possibilities for minimizing systemic toxicities of methotrexate (MTX) and overcoming its resistance. Gelatin-MTX conjugates prepared by a carbodiimide reaction were crosslinked with glutaraldehyde to form microspheres (MTX:gelati