Graft-versus-host disease: an alternative hypothesis
β Scribed by Robertson Parkman
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 498 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0167-5699
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Chronic graft versus host disease continues to be a major problem following bone marrow transplantation even though the incidence and severity of acute graft versus host disease has been reduced. Recent investigations have suggested that the pathogenesis of chronic graft versus host disease is more
Graft-versus-host disease (GVHD) has been the primary limitation to the wider application of allogeneic bone marrow transplantation (BMT). The pathophysiology of acute GVHD is complex and can be conceptualized to be a three-step process based on murine studies. In step 1, the conditioning regimen le