Grading the severity of cervical neoplasia based on combined histopathology, cytopathology, and HPV genotype distribution among 1,700 women referred to colposcopy in Oklahoma
✍ Scribed by Nicolas Wentzensen; Mark Schiffman; S. Terence Dunn; Rosemary E. Zuna; Joan Walker; Richard A. Allen; Roy Zhang; Mark E. Sherman; Sholom Wacholder; Jose Jeronimo; Michael A. Gold; Sophia S. Wang
- Book ID
- 102271350
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- French
- Weight
- 254 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Diagnosis and treatment of cervical cancer precursors rely on colposcopic biopsy, which is sometimes hampered by incorrect biopsy placement and the unclear prognostic value of poorly reproducible diagnoses such as cervical intraepithelial neoplasia (CIN) Grade 1 and 2. Searching for discrete disease categories that incorporate the value of cytology and that reflect the causal role of particular HPV types, we analyzed histology, cytology and HPV genotype distributions in the Study to Understand Cervical Cancer Endpoints and Early Determinants (SUCCEED). This cross‐sectional study comprises ∼1,700 women referred to colposcopy or treatment for the spectrum of cervical disease, including 439 women with i) HPV‐positive women with ii) HPV positive women with iii) CIN2, including histologic CIN2 and HSIL cytology with any histology iv) CIN3; and (v) invasive cervical cancer. The grouping of women with HSIL cytology, but without histological abnormalities to women with CIN2 suggests that in these cases the worst lesion was missed during colposcopy‐biopsy. We are now using these sharpened diagnostic categories to search for novel biomarkers predicting the risk of progression and invasion. © 2008 Wiley‐Liss, Inc.