Grading of CNS neoplasms using continuous arterial spin labeled perfusion MR imaging at 3 Tesla
✍ Scribed by Ronald L. Wolf; Jiongjiong Wang; Sumei Wang; Elias R. Melhem; Donald M. O'Rourke; Kevin D. Judy; John A. Detre
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 383 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1053-1807
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Purpose
To differentiate glioma grade based on blood flow measured using continuous arterial spin labeled (CASL) perfusion MRI, implemented at 3 Tesla for improved signal‐to‐noise ratio (SNR) and spin labeling effect.
Materials and Methods
CASL perfusion images were obtained preoperatively in 26 patients with brain neoplasms (19 high‐grade gliomas (HGGs; WHO grades 3 and 4) and seven low‐grade gliomas (LGGs; WHO grades 1 and 2)). The mean and maximum tumor blood flow (TBF and TBF~max~) were calculated in the neoplasm, including surrounding infiltrating tumor vs. edema. Measures normalized to global CBF (nTBF and nTBF~max~) were also obtained.
Results
Normalized measures of TBF~max~ provided the best distinction between HGG and LGG groups (Wilcoxon rank sum test, P = 0.01). Seventeen of 19 HGGs showed nTBF~max~ > 1.0, and 15 of 19 showed nTBF~max~ > 1.3. Four of seven LGGs showed nTBF~max~ < 1.0, and six of seven showed nTBF~max~ < 1.3. Absolute TBF~max~ also differed significantly between the HGG and LGG groups (P = 0.04). TBF~max~ in 11 of 17 HGGs was >50 mL/100 g/min (mean ± SD = 94.9 ± 71.7 mL/100 g/min). All but one LGGs showed TBF~max~ ≤ 50 mL/100 g/min (mean ± SD = 42.8 ± 22.0 mL/100 g/min).
Conclusion
CASL perfusion MRI provides a quantitative, noninvasive alternative to dynamic susceptibility contrast perfusion MR methods for evaluating gliomas. J. Magn. Reson. Imaging 2005. © 2005 Wiley‐Liss, Inc.