✦ LIBER ✦

Gr-1+CD11b+ myeloid-derived suppressor cells: Formidable partners in tumor metastasis

✍ Scribed by Li Yang; Claire M Edwards; Gregory R Mundy

Publisher: American Society for Bone and Mineral Research
Year: 2010
Tongue: English
Weight: 141 KB
Volume: 25
Category: Article
ISSN: 0884-0431
DOI: 10.1002/jbmr.154

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✦ Synopsis

The growth and metastasis of solid tumors not only depends on their ability to escape from immune surveillance but also hinges on their ability to invade the vasculature system as well as to induce the formation of new blood vessels. Gr-1^+^CD11b^+^ myeloid-derived suppressor cells (MDSCs), overproduced in tumor-bearing hosts, contribute significantly to all these aspects. They also have a potential role in the osteolysis associated with bone metastases. They are formidable partners in tumor metastasis. © 2010 American Society for Bone and Mineral Research.

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## Abstract Tumor‐associated factors are related to increased accumulation of CD11b^+^Gr1^+^myeloid‐derived suppressor cells (MDSCs). However, the exact mechanism of how genetic factors control the expansion of MDSCs in tumor‐bearing hosts remains elusive. Herein, we found that tumor‐associated MDS