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GPR3 orphan receptor is involved in neuropathic pain after peripheral nerve injury and regulates morphine-induced antinociception

✍ Scribed by Jessica Ruiz-Medina; Catherine Ledent; Olga Valverde


Book ID
116785649
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
920 KB
Volume
61
Category
Article
ISSN
0028-3908

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We have previously shown that activation of the ATP-gated ion channel subtype P2X 4 receptors (P2X 4 Rs) in the spinal cord, the expression of which is upregulated in microglia after nerve injury, is necessary for producing neuropathic pain. The upregulation of P2X 4 Rs in microglia is, therefore, a