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Gossypol decreases tumor necrosis factor-α-induced intercellular adhesion molecule-1 expression via suppression of NF-κB activity

✍ Scribed by Dong-Oh Moon; Yung Hyun Choi; Sung-Kwon Moon; Wun-Jae Kim; Gi-Young Kim


Book ID
116463681
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
769 KB
Volume
49
Category
Article
ISSN
0278-6915

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## Abstract ## Objective To investigate the roles of MAPKs and NF‐κB in tumor necrosis factor α (TNFα)–induced expression of vascular cell adhesion molecule 1 (VCAM‐1) in human rheumatoid arthritis synovial fibroblasts (RASFs). ## Methods Human RASFs were isolated from synovial tissue obtained f