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Go!Poly: A gene-oriented polymorphism database

✍ Scribed by Ge Zhang; Sizhong Zhang; Wei Chen; Weimin Qiu; Hui Wu; Jianmin Wang; Jingchu Luo; Xiaocheng Gu; Richard G.H. Cotton

Book ID
102258843
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
385 KB
Volume
18
Category
Article
ISSN
1059-7794

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✦ Synopsis

Human genome polymorphisms play a key role in defining the molecular basis of phenotypic differences between individuals in aspects such as disease susceptibility and drug responses. The database requirements for supporting the study of human genetic variation have been well recognized. In order to meet these needs, several generalized databases have been built. However, it is still hard for users to find gene-related variation data from these huge and sophisticated databases.

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## Communicated by A. Jamie Cuticchia There is a need for country/population-specific databases because the existence of population-specific mutations for single gene disorders is well documented, and there is also good evidence for ethnic differences in the frequencies of genetic variations invol