Goodpasture's syndrome in childhood: Treatment with plasmapheresis and immunosuppression
✍ Scribed by Leo J. McCarthy; Jenny Cotton; Constance Danielson; Vicki Graves; Jerry Bergstein
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 465 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0733-2459
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Goodpasture's syndrome rarely affects children. Therefore, we present our experience in a young boy whose pulmonary hemorrhage was dramatically resolved by three plasma exchanges. We believe the hemorrhage was caused primarily by acute capillaritis. He received cytoxan and steroids and a series of plasma exchanges which removed/suppressed his anti‐glomerular basement membrane (anti‐GBM) antibody production. However, after a year, his renal function did not return, and he required renal transplantation and continues to do well.
📜 SIMILAR VOLUMES
A patient with a hyper-IgE syndrome was treated with 60 plasmaphereses over a period of 2 years in conjunction with cytotoxic immunosuppressive drug therapy. During this time her severe dermatitis of 8 years' duration became almost completely inactive, and her circulating IgE level was reduced by 73
## Abstract We report on 41 patients with Guillain‐Barré Syndrome (GBS) with disability grade 4 and 5 who were treated with manual plasma exchange (PE). Approximately 20‐40 ml/kg body weight of plasma was removed with each manual PE; 63% of patients needed one PE, 24% needed two, 10% needed three,
Therapeutic plasma exchange (TPE) is a standard treatment in Guillain-Barre ´syndrome. TPE may require exogenous fluid for replacement of plasma and, depending on the equipment used, varying extracorporeal volumes. Potential adverse effects include allergic reaction, infection, and hypotension. From