Good adherence to imatinib therapy among patients with chronic myeloid leukemia—a single-center observational study
✍ Scribed by Sofia Jönsson; Bob Olsson; Jenny Söderberg; Hans Wadenvik
- Book ID
- 113027896
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 132 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0939-5555
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## Abstract ## BACKGROUND. Lonafarnib is an orally bioavailable nonpetidomimetic farnesyl transferase inhibitor with significant activity against BCR‐ABL‐positive cell lines and primary human chronic myeloid leukemia (CML) cells. Lonafarnib can inhibit the proliferation of imatinib‐resistant cells
Imatinib mesylate (IM) therapy leads to a complete cytogenetic response (CCyR) in 75-90% of Chronic Myeloid Leukemia (CML) patients in chronic phase, but only a small percentage of patients achieve complete molecular response (CMR). Very little is known about IM discontinuation. We report the case o