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Gold-Catalyzed Formal 1,6-Acyloxy Migration Leading to 3,4-Disubstituted Pyrrolidin-2-ones

โœ Scribed by Hashmi, A. Stephen K.; Yang, Weibo; Yu, Yang; Hansmann, Max M.; Rudolph, Matthias; Rominger, Frank


Book ID
118752338
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
822 KB
Volume
52
Category
Article
ISSN
0044-8249

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โœ Roberta Galeazzi; Giovanna Mobbili; Mario Orena ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 825 KB

Intramolecular conjugate addition of amide enolates to ct,l~-unsaturated esters was found to give either of the diastereomeric trans-3,4-disubstituted pyrrolidin-2-ones 6, 10 or 7, 11 as the major products, by choosing the appropriate reaction conditions. The cyclisation performed with Nail in THF a