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Gold-Catalyzed Cyclization of Nonterminal Propargylic Amides to Substituted Alkylideneoxazolines and -oxazines

โœ Scribed by A. Stephen K. Hashmi; Andreas M. Schuster; Martin Schmuck; Frank Rominger


Book ID
102831401
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
960 KB
Volume
2011
Category
Article
ISSN
1434-193X

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Ring-opening of oxiranes 1 by the silicon-and sulfur-phenylthiofurans 5 is achieved by reaction with palladium(II) acetate. The corresponding furans 7 are obtained when functionalized propargyl anions 2 yields the corresponding alk-4-yn-1-ols 3. Cyclization of 3 to 2,3-dihydro-4-copper(II) chloride