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GMP protects against quinolinic acid-induced loss of NADPH-diaphorase-positive cells in the rat striatum

✍ Scribed by César Malcona; Matilde Achaval; Fábio Komlos; Wania Partata; Maurı́cio Sauressig; Galo Ramı́rez; Diogo O Souza

Book ID: 117475336
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 384 KB
Volume: 225
Category: Article
ISSN: 0304-3940
DOI: 10.1016/s0304-3940(97)00225-5

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## Abstract Symptoms in the early stages of Huntington's disease (HD) are assumed to reflect basal ganglia circuit dysfunction secondary to degeneration of striatal projections to the external segment of the globus pallidus (GPe). The hypothesis that GPe lesion would ameliorate HD symptoms by “norm