Gm allotypes in white patients with systemic lupus erythematosus

✍ Scribed by Peter H. Schur; Janardan P. Pandey; Joseph A. Fedrick

• Book ID: 101645490
• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 231 KB
• Volume: 28
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780280716

✦ Synopsis

There is increasing evidence that genetic factors may play some role in the pathogenesis of systemic lupus erythematosus (SLE). The observations that support this hypothesis include: an increased concordancy of SLE in identical twins (1); an increased frequency of SLE and autoimmune phenomena in relatives of SLE patients (2); an increased frequency of certain sixth chromosomal markers, including IILA-B8, HLA-DR3, and HLA-DR2, C2 deficiency, C4 deficiency, and parental HLA haplotype sharing (3-7); and decreased levels of red blood cell receptors for C3b (8). Based on mathematic considerations, Winchester (9) has suggested that there are 4 genes involved in the pathogenesis of SLE (9). A number of recent studies have suggested that immunoglobulin genes may also contribute to the expression of SLE among Japanese, Australians, and black Americans (10)(11)(12). With these observations and with the knowledge that different ethnic groups have a distinct array of Gm phenotypes, we examined a group of white American SLE patients to determine whether there -From the Robert B.