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Glycosylation and secretion of human alpha-1-antitrypsin by yeast

✍ Scribed by Moir, Donald T.; Dumais, Dennis R.

Book ID
122354523
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
945 KB
Volume
56
Category
Article
ISSN
0378-1119

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Human alpha 1-antitrypsin (alpha 1-AT) is a major serine protease inhibitor in plasma, secreted as a glycoprotein with a complex type of carbohydrate at three asparagine residues. To study glycosylation of heterologous proteins in yeast, we investigated the glycosylation pattern of the human alpha 1