Glycosylated nordihydroguaiaretic acids as anti-cancer agents

✍ Scribed by Jih Ru Hwu; Chuan-I Hsu; Ming-Hua Hsu; Yu-Chuan Liang; Ru Chih C. Huang; Yuan C. Lee

• Book ID: 104005079
• Publisher: Elsevier Science
• Year: 2011
• Tongue: English
• Weight: 264 KB
• Volume: 21
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.10.137

✦ Synopsis

Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose) 4 (12b) and NDGA-(triazol-glucose) 4 (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.