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Glycosylated diazeniumdiolates: a novel class of enzyme-activated nitric oxide donors

✍ Scribed by Xuejun Wu; Xiaoping Tang; Ming Xian; Peng George Wang

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
101 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

Synthetic procedures have been developed to attach the nitric oxide releasing diazeniumdiolate functional groups [N(O)NO] -to a carbohydrate unit. These glycosylated diazeniumdiolates exhibited significantly improved stability as compared to their parent diazeniumdiolate salts, yet they could readily release nitric oxide upon activation by glycosidases. Preliminary antitumor screen assay demonstrated that this class of compounds had antitumor activity.

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