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Glycosyl-inositol deivatives II. Synthesis of 2-amino-2-deoxy-D galactosyl-α-1,3-D-chiro-inositol

✍ Scribed by William K Berlin; Sho-Nong Wang; T.Y Shen

Publisher: Elsevier Science
Year: 1990
Tongue: French
Weight: 221 KB
Volume: 31
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)88738-9

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✦ Synopsis

The "aside method" has been applied to the preparation of a 2amino-2-deoxy-a-Q-galactosyl-Q-m-inositol disaccharide, using silver perchlorate and silver carbonate as the coupling reaction catalysts. A family of glycosyl phosphatidyl inositols (GPI) has been recognized recently as versatile anchor systems for various cell-surface proteins, including enzymes, receptors, antigens and immunological factors.' The generic structure of GPI may be depicted as: Phosphatidyl inositol-hexosamine-hexoses-mannose-6-phosphate--protein a.

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