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Glycosphingolipid storage leads to the enhanced degradation of the B cell receptor in Sandhoff disease mice

✍ Scribed by Danielle te Vruchte; Aruna Jeans; Frances M. Platt; Daniel John Sillence


Book ID
106374602
Publisher
Springer
Year
2010
Tongue
English
Weight
439 KB
Volume
33
Category
Article
ISSN
0141-8955

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✍ Yan-Dong Wang; Wei-Dong Chen; Donna Yu; Barry M. Forman; Wendong Huang πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 934 KB

Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. TGR5 also displays strong attenuation of macrophage reactivity in vitro, but the physiological roles of TGR5 in inflammatory response, and its mechanism, is unk