Glycosidation, IX. Synthesis of functionalised acetals for coupling with monoclonal antibodies and other biopolymers
✍ Scribed by Tietze, Lutz F. ;Goerlach, Ada ;Beller, Matthias
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 541 KB
- Volume
- 1988
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
For coupling of acctal-glycosidcs 3 and 4 of cytotoxic aldchydes with biopolynicrs for thc sclcctivc trcatmcnt of cancer, acctals of typc 5 or 6. which bcar a carhoxylic cstcr function or an acylatcd amino group in the alcohol moiety. wcre prepared by reaction of aldehydes 7a-d and the trimethylsilyl ethers 8a-d in the presence of a catalytic amount of trimethylsilyl trifluoromethanesulfonatc.
The numbering of all carbon and hydrogen atoms was carried out according to the IUPAC rules, except for the ethylene bridge in the aromatic alcohol, the position numbers of which are marked with an asterisk (*). This was done to harmonise the numbering in acetal-glucosides of aromatic and aliphatic acetals.