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Glycosaminoglycans reduce oxidative damage induced by copper (Cu+2), iron (Fe+2) and hydrogen peroxide (H2O2) in human fibroblast cultures

✍ Scribed by Giuseppe M. Campo; Angela D'Ascola; Angela Avenoso; Salvatore Campo; Alida M. Ferlazzo; Carmelo Micali; Laura Zanghì; Alberto Calatroni

Book ID
111583676
Publisher
Springer US
Year
2003
Tongue
English
Weight
147 KB
Volume
20
Category
Article
ISSN
1573-4986

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Oxidative damage to sarcoplasmic reticul
Oxidative damage to sarcoplasmic reticulum Ca2+-pump induced by Fe2+/H2O2/ascorbate is not mediated by lipid peroxidation or thiol oxidation and leads to protein fragmentation
✍ Roger F. Castilho; Paulo C. Carvalho-Alves; Anibal E. Vercesi; Sérgio T. Ferreir 📂 Article 📅 1996 🏛 Springer 🌐 English ⚖ 904 KB

The major protein in the sarcoplasmic reticulum (SR) membrane is the Ca2+ transporting ATPase which carries out active Ca2+ pumping at the expense of ATP hydrolysis. The aim of this work was to elucidate the mechanisms by which oxidative stress induced by Fenton's reaction (Fe(2+)+H2O2-->HO.+OH-+Fe3