✦ LIBER ✦

Glycoprotein gB of herpes simplex virus expresses type-common and type-specific antigenic determinants in vivo

✍ Scribed by Dr. Richard D. Dix

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 494 KB
Volume: 30
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890300309

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✦ Synopsis

Abstract

Four monoclonal antibodies directed against glycoprotein B of herpes simplex virus were evaluated for their ability to immunize mice passively against acute virus‐induced neurological illness and death when administered intraperitoneally 2 hours prior to footpad challenge with type 1 or type 2 virus. Two monoclonal antibodies, H120 and H157, failed to reduce the severity of neurological disease in infected animals. In contrast, H233 and H368 antibodies provided significant protection in type‐common and type‐specific fashions, respectively. A direct correlation was observed between in vitro neutralization and in vivo protection. These results provide the first in vivo evidence that glycoprotein gB of herpes simplex virus expresses both type‐common and type‐specific determinants during the evolution of acute virus‐induced neurological disease.

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