Glycoprobes as a tool for the study of lectins expressed on tumor cells
β Scribed by Olga Kurmyshkina; Eugenia Rapoport; Ekaterina Moiseeva; Elena Korchagina; Tatiana Ovchinnikova; Galina Pazynina; Ivan Belyanchikov; Nicolai Bovin
- Book ID
- 113416126
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- German
- Weight
- 363 KB
- Volume
- 112
- Category
- Article
- ISSN
- 0065-1281
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## Abstract To improve tumor targeting in a subset of patients, where tumor cells do not express the wellβknown tumor antigens widely used in immunotherapy, we have developed a novel biotechnological tool. It is useful for tumors of various origins for the identification of tumorβassociated protein
The possibility that a plant lectin as a carrier protein would specifically activate T cells, resulting in the augmentation of antitumor immunity was investigated. ATF10t l, a nonmitogenic lectin for T cells purified from Aloe arborescens Mill, bound equally to normal and tumor cells. ATF1011 bindin