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Glycolytic metabolism confers resistance to combined all-trans retinoic acid and arsenic trioxide-induced apoptosis in HL60ρ0 cells

✍ Scribed by Patries M. Herst; Elizabeth L. Hesketh; David S. Ritchie; Michael V. Berridge

Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
676 KB
Volume
32
Category
Article
ISSN
0145-2126

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Acute promyelocytic leukemia (APL) is highly malignant and frequently expresses the PML-RAR␣ (promyelocytic leukemia-retinoic acid receptor-␣) fusion protein. This fusion protein is targeted by all-trans retinoic acid (ATRA) and arsenic trioxide (As 2 O 3 ), presently used in APL therapy. We have ev