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Glycogen synthase kinase-3β plays a pro-apoptotic role in β-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes: Role of β1 integrins

✍ Scribed by Bindu Menon; Jennifer N. Johnson; Robert S. Ross; Mahipal Singh; Krishna Singh


Book ID
116984545
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
880 KB
Volume
42
Category
Article
ISSN
0022-2828

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## Abstract We have shown that the stimulation of β‐adrenergic receptors (β‐AR) increases apoptosis in adult rat ventricular myocytes (ARVMs). Integrins, a family of αβ‐heterodimeric cell surface receptors, are postulated to play a role in ventricular remodeling. Here, we show that norepinephrine (