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Glycine intrastriatal administration induces lipid and protein oxidative damage and alters the enzymatic antioxidant defenses in rat brain

✍ Scribed by Bianca Seminotti; Lisiane Aurélio Knebel; Carolina Gonçalves Fernandes; Alexandre Umpierrez Amaral; Mateus Struecker da Rosa; Paula Eichler; Guilhian Leipnitz; Moacir Wajner

Book ID: 116720030
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 279 KB
Volume: 89
Category: Article
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2011.06.013

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## Abstract In the present work we investigated the in vitro effect of 3‐hydroxy‐3‐methylglutarate (HMG) that accumulates in 3‐hydroxy‐3‐methylglutaryl‐CoA lyase deficiency (HMGLD) on important parameters of oxidative stress in rat cerebral cortex. It was observed that HMG induced lipid peroxidatio