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Glycan and lectin microarrays for glycomics and medicinal applications

✍ Scribed by Jaroslav Katrlík; Juraj Švitel; Peter Gemeiner; Tibor Kožár; Jan Tkac

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
381 KB
Volume
30
Category
Article
ISSN
0198-6325

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✦ Synopsis

Abstract

Three different array formats to study a challenging field of glycomics are presented here, based on the use of a panel of immobilized glycan or lectins, and on in silico computational approach. Glycan and lectin arrays are routinely used in combination with other analytical tools to decipher a complex nature of glycan‐mediated recognition responsible for signal transduction of a broad range of biological processes. Fundamental aspects of the glycan and lectin array technology are discussed, with the focus on the choice and availability of the biorecognition elements, fabrication protocols, and detection platforms involved. Moreover, practical applications of both technologies especially in the field of clinical diagnostics are provided. The future potential of a complementary in silico array technology to reveal details of the protein–glycan‐binding profiles is discussed here. © 2010 Wiley Periodicals, Inc. Med Res Rev, 30, No. 2, 394–418, 2010

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